Folate and nitrate-induced endothelial dysfunction: a simple treatment for a complex pathobiology.

نویسنده

  • J Loscalzo
چکیده

Organic nitrates have served as mainstays of therapy for the treatment of coronary artery disease for more than a century. Their use, however, has been complicated by unwanted side effects, including hypotension and the development of nitrate tolerance. Nitrate tolerance is a term used to define tachyphylaxis to nitrates with long-term use. The mechanisms of nitrate tolerance have been debated for some time and include depletion of thiols, an increase in venous blood volume limiting vasodilator responsiveness, and increased generation of reactive oxygen species.

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عنوان ژورنال:
  • Circulation

دوره 104 10  شماره 

صفحات  -

تاریخ انتشار 2001